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Lipoproteins in Diabetes Mellitus

Diabetes mellitus (DM) is becoming increasingly epidemic globally. The World Health Organization (WHO) estimates that the prevalence of DM varies between 8 and 10 % in all regions of the globe. Millions of new cases are diagnosed every year, and a substantial percentage of people with DM are undiagnosed either because they are not screened for the condition or because of inadequate access to healthcare.

The epidemics of obesity, increased mechanization and reduced physical activity, cigarette smoking, and the fact that people are living longer have all contributed to the rise in Type 2 DM incidence. The incidence and prevalence of Type 1 DM is also increasing, perhaps also related to changes in the environment.

Obesity, sedentary lifestyle, and cigarette smoking potentiate insulin resistance, which also promote atherosclerosis and the vascular complications of DM, as well as of Type 2 DM itself. Longer lifespan is associated with increased weight, lower levels of physical activity, and progressive loss of pancreatic islet cell mass.

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Biochemistry – satyanarayan

I owe a deep debt of gratitude to my parents, the late Sri U. Venkata Subbaiah, and Smt. Vajramma, for
cultivating in me the habit of early rising. The writing of this book would never have been possible without
this healthy habit. I am grateful to Dr. B. S. Narasinga Rao (former Director, National Institute of Nutrition,
Hyderabad) for disciplining my professional life, and to my eldest brother Dr. U. Gudaru (former Professor of
Power Systems, Walchand College of Engineering, Sangli) for disciplining my personal life.

My elder son, U. Chakrapani (MBBS) deserves a special place in this book. He made a significant contribution at every stage of its preparation-writing, verification, proof-reading and what not. I had the rare privilege of teaching my son as he happened to be a student of our college. And a major part of this book was written while he was learning biochemistry.

Thus, he was the first person to learn the subject of biochemistry from my handwritten manuscript. The student-teacherelation (rather than the father-son) has helped me in receivinSl constant feedback from him and restructure the book in a way an undergraduate student would expect a biochemistry textbook to be.

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